Niklaus Manuel Deutsch (1484–1530), also known as Niklaus Manuel, was a Swiss artist, writer, and politician. Born in Bern, he was a prominent figure during the Reformation period. Deutsch's diverse talents and interests made him a multifaceted personality of his time.

As an artist, Deutsch is noted for his work as a painter, draftsman, and woodcut artist. His art often reflected the religious and political upheaval of his era, with a particular focus on critiquing the Catholic Church and promoting Reformation ideas. His style combined elements of late Gothic and early Renaissance art, marked by expressive detail and a keen eye for narrative.

Deutsch was also actively involved in politics, serving as a member of the Bernese government. His written works, including plays and satirical poems, further exhibit his engagement with the social and religious issues of his time. Despite his relatively short life, Niklaus Manuel Deutsch left a significant impact on Swiss art and the cultural landscape of the Reformation period, remembered for his artistic skill and his contributions to the intellectual and political discourse of his era.